Progetti

Progetti di ricerca in corso basati sui dati SCQM

Con i nostri dati sosteniamo la ricerca nel campo delle malattie reumatiche infiammatorie. Una panoramica dei progetti di ricerca in corso è disponibile qui.

Vorremmo incoraggiare i reumatologi svizzeri a partecipare a progetti di ricerca che utilizzano i dati SCQM. Se desiderate saperne di più su un progetto in corso o volete contribuire, contattate il nostro responsabile scientifico Almut Scherer (almut.scherer_at_scqm.ch).

Ultimi progetti:

  • Comparison of DAS 28 (Disease Activity Score) and CDAI (Clinical Disease Activity Index)/ SDAI (Simplified Disease Activity Index) scores: Which score better assesses remission or low disease activity (LDA) in patients with rheumatoid arthritis?
  • Is peripheral joint response to IL-17 inhibition in the spondyloarthritides site-specific? A European cohort study in psoriatic arthritis and axial spondyloarthritis
  • Validity and reliability of the Disease Activity index for Psoriatic Arthritis (DAPSA) and DAPSA-28 in European patients with Psoriatic Arthritis (PsA)
  • The MRI equivalent to modified New York criteria-positivity on conventional radiography of the sacroiliac joints
  • The association between MRI sacroiliac joint and spine inflammation and structural lesions, physical function and spinal mobility, and other outcome measures

Numero del progetto Titolo Responsabile del progetto
2023_25 Is peripheral joint response to IL-17 inhibition in the spondyloarthritides site-specific? A European cohort study in psoriatic arthritis and axial spondyloarthritis Adrian Ciurea, USZ
2023_24 Validity and reliability of the Disease Activity index for Psoriatic Arthritis (DAPSA) and DAPSA-28 in European patients with Psoriatic Arthritis (PsA) Michael Nissen
2023_17 Comparison of DAS 28 (Disease Activity Score) and CDAI (Clinical Disease Activity Index)/ SDAI (Simplified Disease Activity Index) scores: Which score better assesses remission or low disease activity (LDA) in patients with rheumatoid arthritis? Rüdiger Müller
2023_13 A comparative cohort analysis of the time to treatment discontinuation and of the effectiveness of upadacitinib and tumor necrosis factor inhibitors in patients with rheumatoid arthritis: analysis of pooled data from RHUMADATA-OBRI-SCQM registries. Denis Choquette, Axel Finckh, Claire Bombardier
2023_10 The role of the kynurenine pathway in regulating macrophage function in rheumatoid arthritis Bojana Müller, Universitätsspital Basel
2023_07 Digital Biomarker for Monitoring and Predicting Disease Severity in the Daily Lives of Rheumatoid Arthritis Patients Raphael Micheroli, USZ
2023_05 Early axial spondyloarthritis: Characterization, response to treatment and spinal radiographic progression in early vs. late disease Adrian Ciurea, USZ
2023_04 Cross-country differences in bDMARD prescription behaviour: associations between socioeconomics, real world bDMARD use and disease outcomes Delphine Courvoisier, HUG
2023_03 Therapeutic drug monitoring of JAK inhibitors as novel precision medicine instrument for acute and chronic inflammatory disorders François Girardin
2022_26 Occurrence and pattern of MRI and radiographic involvement of sacroiliac joints and spine in a European cohort of real-life patients with psoriatic arthritis Adrian Ciurea, USZ
2022_22 The MRI equivalent to modified New York criteria-positivity on conventional radiography of the sacroiliac joints Adrian Ciurea, USZ
2022_21 Cohort profile: the SCQM polymyalgia rheumatica and giant cell arteritis cohort Thomas Daikeler
2022_19 Real world data on Evusheld use and burden of disease of covid19 threat in patients with inflammatory rheumatic diseases Kim Lauper
2022_18 The association between MRI sacroiliac joint and spine inflammation and structural lesions, physical function and spinal mobility, and other outcome measures Adrian Ciurea, USZ
2022_17 Mechanistic modelling-based prediction of humoral vaccine responses in immuno-modulated patients with inflammatory rheumatic diseases after mRNA COVID-19 vaccination Christoph Berger, Andrea Rubbert-Roth
2022_16 Chondrocalcinosis in Rheumatoid Arthritis: an imaging analysis on correlation with disease activity and radiographic progression of Osteoarthritis Tobias Manigold, Thomas Hügle
2022_15 Explore the incidence of adverse events in patients treated with conventional and/or biological DMARDs Michael Nissen
2022_14 Explore the impact of selected comorbidities and extraarticular manifestations on prescription patterns and treatment effectiveness Michael Nissen
2022_11 Automated Dorsal Finger Fold Pattern Recognition on Real World Hand Photos as a Potential Digital Biomarker for the activity of Rheumatoid Arthritis Thomas Hugle
2022_09 EuroSpA area E: Data mapping survey study Michael Nissen
2022_08 Investigation of ASDAS-ESR cut-offs values for disease activity states in axial spondyloarthritis Adrian Ciurea, USZ
2022_07 Comparison of damage progression on MRI and conventional radiography of the sacroiliac joints in axial spondyloarthritis Raphael Micheroli, USZ
2022_06 Local vs. central readings of MRIs of the sacroiliac joints in patients with axial spondyloarthritis: investigation of agreement and the need for educational activities for local interpreters” for your information Adrian Ciurea, USZ
2022_05 Distribution of sacroiliac joint and spine imaging findings in a large cohort of real-life patients with axial SpA Adrian Ciurea, USZ
2022_04 Progression of sacroiliac joint and spinal structural changes in a European cohort of real-life patients with axial spondyloarthritis and psoriatic arthritis: A longitudinal analysis of magnetic resonance and X-ray images. Adrian Ciurea, USZ
2022_01 Gender-attributable differences in patient reported outcome measures in axial spondyloarthritis. Raphael Micheroli
2021_15 Ultrasonographic differences of synovitis grade between joint locations in rheumatoid arthritis Raphael Micheroli
2021_14 Impact of work-related physical stress on the response to different biologics in psoriatic arthritis Raphael Micheroli
2021_13 Impact of the Covid-19 pandemic on patient selection and treatment outcomes in spondyloarthritis patients treated with b/tsDMARDs across Europe Kim Lauper
2021_12 Analysis of immune-tolerance in individuals with pathogenic mutations in the immunoglobulin kappa (k) light chain Mike Recher, Diego Kyburz
2021_11 Treatment retention in SpA patients assessed with methods for interval- censored time-to-event data Myriam Riek, Seraphina Kissling, Adrian Ciurea
2021_09 A potential role of Chlamydia infection in Rheumatoid Arthritis development Céline Lamacchia
2021_08 Patient Clusters in Rheumatoid Arthritis Identified by Deep Learning Respond Differently to Biologic or Targeted Synthetic DMARDs Thomas Huegle
2021_07 Impact of national treatment guidelines, schedules of reimbursement and gross domestic product on treatment outcomes in patients treated with b/tsDMARDs across European observational spondyloarthritis registries Adrian Ciurea
2021_05 Understanding the impact of COVID-19 on the anti-apoA-1 IgG response in inflammatory rheumatism disorders Nicolas Vuilleumier, Axel Finckh
2021_04 Understanding the heterogeneity in patient populations across EuroSpA registries - the role of national access and treatment guidelines Michael Nissen
2021_03 Patient reported outcomes, drug adherence and clinical effectiveness of secukinumab in patients with psoriatic arthritis and axial spondylarthritis up to24 months: Results from the EuroSpA collaboration. Burkhard Möller
2021_02 Is uveitis associated with a more severe axial disease phenotype in axial spondyloarthritis? Adrian Ciurea
2021_01 Investigating drug-induced Chronic Kidney Disease using a pharmacogenomics approach in a multicentric framework Project Alexander Leichtle, Burkhard Möller
2020_21 Comparison of drivers of the associations of obesity and rheumatoid arthritis disease activity and of obesity and erosive progression Andrea Burden, Thomas Huegle
2020_20 Treatment of peripheral arthritis in the spondyloarthritides: Joint-specific response to TNF inhibitors? Adrian Ciurea
2020_19 Enthesitis in psoriatic arthritis and axial spondyloarthritis: Pattern, risk factors, and effectiveness of tumor necrosis factor inhibitors - A EuroSpA collaboration study Michael Nissen
2020_17 Real-world dynamics of anti-S1-binding antibodies after COVID-19 vaccination in patients with inflammatory rheumatic diseases Andrea Rubbert-Roth, Axel Finckh
2020_16 Sex and gender differences in response to biologics among patients with rheumatoid arthritis in Switzerland. Andrea Burden, Axel Finckh, Rafi Micheroli, Burkhard Möller
2020_12 Description and assessment of treatment gaps in rheumatoid arthritis advanced treatment Andrea Burden, Axel Finckh, Thomas Hugle
2020_11 EuroSpA-D: Handling of missing component values in patient-reported outcomes Stylianos Georgiadis, Myriam Riek, Swiss PI (Micheal Nissen)
2020_09 Vaccination in patients with rheumatic diseases Kim Lauper
2020_06 Psoriasis and Axial Involvement in Spondyloarthritis Adrian Ciurea
2020_04 Effectiveness of Abatacept and alternative biologic antirheumatic agents according to the shared epitope: The EASE study Axel Finckh
2020_03 Risk factors of infection with SARS-CoV-2 and of a serious course of COVID-19 in inflammatory rheumatic diseases in Switzerland Axel Finckh
2020_02 The effectiveness of a therapeutic change in RA patients with radiographic progression despite low disease activity Ruediger Mueller, Lena Brandt
2020_01 Prediction of erosions in RA by different modifications of the standard SONAR score Burkhard Moeller
2019_24 Prediction of remission, response and retention in patients with psoriatic arthritis and axial spondyloarthritis treated with TNF-inhibitors Michael Nissen, Adrian Ciurea, Burkhard Moeller
2019_22 Response tolerance measures in rheumatology Myriam Riek
2019_21 Comparative treatment efficacy in rheumatoid arthritis with and without concomitant Sjoegren syndrome (CoRASS) Lisa Christ, Florian Kollert, Burkhard Möller
2019_20 Differences in burden of disease, treatment standard and response in patients with Psoriasis Arthritis in case of fulfilling vs not-fulfilling RCT joint count criteria Burkhard Moeller
2019_18 SONAR SpA Validation study Michael Nissen, Pascal Zufferey
2019_16 Predictors for loss of productivity and the effect of b/tsDMARD treatment on loss of productivity in Swiss patients with rheumatoid arthritis Diego Kyburz
2019_13 Development of a prediction score for response to biological or targeted synthetic DMARDs in patients with inflammatory rheumatic diseases by combining clinical and -omics data Britta Maurer, Caroline Ospelt
2019_12 Real world effectiveness of baricitinib in the Swiss RA registry Axel Finckh
2019_11 European collaborative analysis of real-world effectiveness of JAKinhibs versus anti-TNF agents and other bDMARDs (Jak-pot) Kim Lauper, HUG
2019_10 Gender differences in Biologicals and targeted synthetic Disease Modifying Anti-Rheumatic Drugs in Spondyloarthritis and psoriatic arthritis Michael Nissen, Adrian Ciurea, Burkhard Moeller
2019_09 Quantifying the effects of lifestyle factors in relation to outcome from bDMARD therapy amongst patients with axSpA and PsA Michael Nissen, Adrian Ciurea, Burkhard Moeller
2019_08 SYSCID: Discovering new biomarkers by large “multi-omics” analysis to identify individuals in pre-clinical stages of Rheumatoid Arthritis C. Lamacchia, Axel Finckh
2019_06 The impact of body mass index on the effectiveness of in inflammatory rheumatic conditions Andrea Burden, Axel Finckh
2019_04 Multimodal-based disease activity indices und risk of progression in rheumatoid arthritis Giorgio Tamborrini (now Pascal Zufferey), P. Mandl
2019_03 Effectiveness of TNFi versus OMA biologica in JAK-IR patients with Rheumatoid arthritis, an observational study Diego Kyburz
2018_18 Deep learning for the prediction of radiographic progression in rheumatoid arthritis Thomas Huegle, Maria Kalweit
2018_16 Comparative efficacy of TNF-inhibitors (TNFi) versus other mode of action (OMA) biological DMARDs in PsA -- an observational study Burkhard Moeller
2018_09 Bone health in PsA patients Diana Dan, Berengere Aubry-Rozier, Daniel Aeberli
2018_07 Translating humoral immunity against apolipoprotein A1 from an emerging CV risk factor to cardiovascular risk stratification tool in IRD Cem Gabay, Nicolas Vuilleumier
2018_04 Effect of rheumatoid arthritis treatments on the incidence of fragility /low trauma fracture Diana Dan
2018_03 Retention and effectiveness of TNF inhibitor treatment in axial spondyloarthritis and psoriatic arthritis: an analysis from the EuroSpA collaboration Michael Nissen, Adrian Ciurea, Cem Gabay, Burkhard Moeller
2018_02 Patient reported outcomes in patients with axial spondyloarthritis and psoriatic arthritis starting treatment with TNF inhibitors: an analysis from the EuroSpA collaboration Michael Nissen, Adrian Ciurea, Cem Gabay, Burkhard Moeller
2017_08 COmPASS II weather sensitivity Ulrich Walker
2017_07 COmPASS II treatment response kinetics Ulrich Walker
2017_06 COmPASS II socioeconomic Ulrich Walker
2017_05 COmPASS II self monitoring and feedback Ulrich Walker
2017_04 COmPASS II correlation and fluctuation Ulrich Walker
2016_14 The TOcilizumab Collaboration of European Registries in RA (TOCERRA) – comparative effectiveness of tocilizumab (MADACTA) Cem Gabay, Kim Lauper
2016_12 Tenosynovitis in Rheumatoid Arthritis: Prevalence, Determinants and Outcome of Tenosynovitis detected in the SONAR-Ultrasound examination in the SCQM Cohort. Raphael Micheroli, Giorgio Tamborrini
2015_09 Analysis of fine anti-citrullinated peptide antibody specificities, anti-carbamylated peptide antibodies and genetic characteristics in psoriatic arthritis patients Michael Nissen
2015_07 Dosage adjustment of anti-tumor necrosis factor-alpha inhibitors in axial spondyloarthritis Adrian Ciurea
2015_03 Impact of axSpA on work participation and the role of anti-TNF treatment Adrian Ciurea
2014_08 The effect of body mass index on the course of disease activity in axial spondyloarthritis Adrian Ciurea, Raphael Micheroli
2014_06 Anemia and perceived disease burden in axial spondyloarthritis Adrian Ciurea, Anne Hofmann, Raphael Micheroli
2014_05 Regular exercise and functional outcomes in axial spondyloarthritis Adrian Ciurea, Mauro Bachmann
2013_06 Gender differences in the SCQM axial SpA cohort Adrian Ciurea
2011_02 Predictors for duration of remission after discontinuation of biologics therapy Diego Kyburz

I progetti di cooperazione internazionale sono elencati solo a titolo informativo. Si prega di notare che l'inclusione di personale aggiuntivo nei progetti internazionali spesso non è possibile a causa delle dimensioni limitate del gruppo di progetto per paese.